(French) form of the Latin name Rosalia (a derivative of rosa ‘rose’), introduced to the English-speaking world in the latter part of the 19th century. St Rosalia was a 12th-century Sicilian virgin, and is the patron of Palermo.
Italian (Sicily): habitational name from a place called Mandracchia, named with medieval Greek mandrakia, plural of mandrakion ‘yard’, a diminutive of mandra ‘enclosure’. It may also be a topographic name for someone living by an enclosure. Mandraki is a common place name in Greece, and Mandrakis is also found as a Greek family name.